Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295789 | 0.85 | CA12 (0.66) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL8775648 | 0.84 | ALDH1A1 (0.56) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL14152011 | 0.81 | MEN1 (0.49) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL27818509 | 0.80 | CTSS (0.56) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL11651843 | 0.79 | CA12 (0.60) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL27880557 | 0.79 | CA12 (0.60) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL234454 | 0.79 | LMNA (0.62) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL27818503 | 0.79 | LMNA (0.48) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL4149248 | 0.78 | ALDH1A1 (0.60) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL28493711 | 0.78 | LMNA (0.57) | LMNASMN1; SMN2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216766-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |