SCHEMBL8775648

SCHEMBL8775648

O=CNC(=O)OCc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
NPC1 O15118 2/20 0.56
POLB P06746 2/20 0.56
RAB9A P51151 2/20 0.56
KMT2A Q03164 2/20 0.56
MEN1 O00255 1/20 0.56
MAPT P10636 1/20 0.56
LMNA P02545 1/20 0.56
CA12 O43570 2/20 0.54
CA1 P00915 2/20 0.54
CA2 P00918 2/20 0.54
CA9 Q16790 2/20 0.54
HTT P42858 1/20 0.53
MAPK1 P28482 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A3 Q01959 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
HCAR2 Q8TDS4 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28207266 0.86 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL483306 0.84 TGM2 (0.56) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL7448378 0.84 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL645150 0.84 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL3928127 0.84 LMNA (0.56) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL14855359 0.84 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL22601809 0.84 LMNA (0.58) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL4291030 0.82 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL1415895 0.82 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2NPC1POLBRAB9A
SCHEMBL2295789 0.82 CA12 (0.66) ALDH1A1SMN1; SMN2NPC1POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5494666-A BETA-LACTAMASE INHIBITORS, ANTIBACTERIALS HOFFMANN-LA ROCHE INC. (US) 1996-02-27 US claimed
US-5464617-A 1H-2,6a-diazacyclobut(cd)indene-6-carboxylic acid derivatives, antibiotics HOFFMANN-LA ROCHE INC. (US) 1995-11-07 US claimed
EP-0671401-A1 Beta lactames F. HOFFMANN-LA ROCHE AG (CH) 1995-09-13 EP claimed
CN-101460198-B Thermosensitive polyphosphazene-bioactive molecule conjugate, preparation method and application thereof KOREA INST SCI & TECH 2013-08-07 CN disclosed
CN-102015658-B Benzimidazole derivatives serving as calcium channel blocker ACTELION PHARMACEUTICALS LTD 2013-03-20 CN disclosed
CN-102015658-A Benzimidazole derivatives ACTELION PHARMACEUTICALS LTD 2011-04-13 CN disclosed
CN-101460198-A Thermosensitive polyphosphazene-bioactive molecule conjugate, preparation method and application thereof KOREA INST SCI & TECH (KR) 2009-06-17 CN disclosed
EP-0796239-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE (S,S) AMINOEPOXIDES, KEY INTERMEDIATES FOR HIV PROTEASE INHIBITORS, VIA THEIR CHLOROHYDRINES BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 1997-09-24 EP disclosed
WO-1996017821-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE (S,S) AMINOEPOXIDES, KEY INTERMEDIATES FOR HIV PROTEASE INHIBITORS, VIA THEIR CHLOROHYDRINES BOEHRINGER INGELHEIM (CANADA) LTD./BOEHRINGER INGELHEIM (CANADA) LTÉE (CA) 1996-06-13 WO disclosed
EP-0308917-A2 Imidazopyridine compound, a process for preparation thereof and pharmaceutical compositions comprising them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-03-29 EP disclosed
EP-0107850-B1 AMINOGLYCOSIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1988-04-06 EP disclosed
US-4656160-A VIRICIDES; HERPES VIRUS; TOBRAMYCINS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1987-04-07 US disclosed
EP-0183241-A2 New aminoglycoside derivatives processes for the preparation and pharmaceutical compositions containing them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1986-06-04 EP disclosed