Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12223976 | 0.77 | CDK2 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23489973 | 0.77 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22508896 | 0.75 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12877806 | 0.75 | NOS1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22930975 | 0.75 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21555218 | 0.74 | SLC6A3 (0.35) | SLC6A3P2RX7 | |
| SCHEMBL24659233 | 0.73 | GPR84 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18857238 | 0.71 | MAPK1 (0.31) | — | |
| SCHEMBL23153450 | 0.71 | SLC6A3 (0.33) | SLC6A3 | |
| SCHEMBL21240710 | 0.71 | FDPS (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667629-B2 | Isoxazole derivative, preparation method therefor, and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| US-20200339558-A1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN-BiOTECH BIGPHARMACEUTICAL CO., LTD. (CN) | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339558-A1 | ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | CYP4A11, CYP4F11, SLC10A1 | PSEN1 2852/4885PSEN2 3174/4885APH1B 2785/4885 |
| US-11667629-B2 | Isoxazole derivative, preparation method therefor, and use thereof | CYP4A11, CYP4F11, SLC10A1 | PSEN1 2852/4885PSEN2 3174/4885APH1B 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.