Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22609379 | 0.86 | MAPT (0.40) | CDC7IDO1MEN1ALDH1A1LMNA | |
| SCHEMBL22609364 | 0.84 | PRKAB2 (0.38) | CDC7MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL22609500 | 0.82 | ABCC8 (0.36) | CDC7PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22609396 | 0.80 | MAPT (0.34) | CDC7MKNK2ALDH1A1LMNAMAPT | |
| SCHEMBL22609420 | 0.76 | ABCC8 (0.32) | ABCC8KCNJ11 | |
| SCHEMBL168203 | 0.73 | TUBB4A (0.43) | CDC7MAPK14GAKPDGFRBKIT | |
| SCHEMBL167755 | 0.73 | IRAK4 (0.39) | CDC7MAPK14GAKPDGFRBKIT | |
| SCHEMBL2911881 | 0.69 | KDM4E (0.34) | ALDH1A1LMNAMAPTMAPK1RAB9A | |
| SCHEMBL8694104 | 0.69 | TRPV1 (0.42) | MAPK14CA1CA2CA4CA9 | |
| SCHEMBL22609407 | 0.68 | MEN1 (0.37) | MEN1ALDH1A1LMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |