Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21070919 | 1.00 | ACKR3 (0.43) | ACKR3SIGMAR1ABCB1CHRM2CHRM4 | |
| SCHEMBL22609550 | 0.84 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL21071086 | 0.84 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL17782082 | 0.80 | SIGMAR1 (0.52) | ACKR3SIGMAR1CHRM2CHRM4CHRM1 | |
| SCHEMBL10321592 | 0.79 | ABCB1 (0.56) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10320993 | 0.79 | ABCB1 (0.56) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL26998993 | 0.79 | SIGMAR1 (0.50) | ACKR3SIGMAR1CHRM2CHRM4CHRM1 | |
| SCHEMBL21070462 | 0.79 | AGTR2 (0.36) | — | |
| SCHEMBL21069624 | 0.77 | SIGMAR1 (0.47) | SIGMAR1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL25326370 | 0.77 | TEAD3 (0.56) | ACKR3SIGMAR1CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |