Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23319482 | 0.78 | HCRTR1 (0.46) | KMT2AALDH1A1HCRTR1HCRTR2HTT | |
| SCHEMBL3793071 | 0.75 | KMT2A (0.55) | KMT2AALDH1A1HTTCYP1A2CYP2C9 | |
| SCHEMBL22609516 | 0.74 | HCRTR1 (0.38) | KMT2AALDH1A1HCRTR1HCRTR2HTT | |
| SCHEMBL30830857 | 0.71 | KMT2A (0.71) | KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL22609555 | 0.70 | MDH2 (0.38) | KMT2AALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL3796336 | 0.70 | KMT2A (0.57) | KMT2AALDH1A1HTTCYP1A2CYP2C9 | |
| SCHEMBL22609475 | 0.69 | KMT2A (0.41) | KMT2AALDH1A1HCRTR1HCRTR2GAA | |
| SCHEMBL22609469 | 0.69 | FADS1 (0.46) | KMT2AALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL26641362 | 0.67 | KMT2A (0.48) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL23319539 | 0.67 | MAT2A (0.40) | KMT2AALDH1A1HCRTR1HCRTR2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121043-A1 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| WO-2021188948-A1 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |