Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22609516 | 0.84 | HCRTR1 (0.38) | HCRTR1HCRTR2KMT2AALDH1A1TP53 | |
| SCHEMBL22609555 | 0.80 | MDH2 (0.38) | HCRTR1HCRTR2KMT2AALDH1A1MAPT | |
| SCHEMBL23319539 | 0.80 | MAT2A (0.40) | HCRTR1HCRTR2KMT2AALDH1A1MAPT | |
| SCHEMBL22609653 | 0.78 | KMT2A (0.39) | HCRTR1HCRTR2KMT2AALDH1A1GAA | |
| SCHEMBL30830857 | 0.78 | KMT2A (0.71) | KMT2AALDH1A1LMNAMEN1SMN1; SMN2 | |
| SCHEMBL3793071 | 0.75 | KMT2A (0.55) | KMT2AALDH1A1LMNAMEN1CYP1A2 | |
| SCHEMBL15906095 | 0.70 | KMT2A (0.46) | HCRTR1HCRTR2KMT2AALDH1A1TP53 | |
| SCHEMBL15455938 | 0.70 | MAPT (0.68) | KMT2AALDH1A1TP53MAPTLMNA | |
| SCHEMBL1735130 | 0.70 | MAPT (0.68) | KMT2AALDH1A1MAPTLMNAGAA | |
| SCHEMBL26641362 | 0.69 | KMT2A (0.48) | KMT2AALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3817748-A1 | TRICYCLIC CRBN LIGANDS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-05-12 | — | — | EP | disclosed |