Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428641 | 0.80 | PKM (0.47) | MGLLHPGDPKMALDH1A1LMNA | |
| SCHEMBL8125415 | 0.74 | CHRM5 (0.41) | HPGDALDH1A1LMNATSHRKMT2A | |
| SCHEMBL23564362 | 0.73 | MGLL (0.38) | MGLLPKMALDH1A1LMNATSHR | |
| SCHEMBL1272645 | 0.72 | ALDH1A1 (0.36) | MGLLHPGDPKMALDH1A1LMNA | |
| SCHEMBL5490567 | 0.72 | HPGD (0.38) | HPGDPKMALDH1A1LMNAKMT2A | |
| SCHEMBL14647288 | 0.72 | PKM (0.36) | HPGDPKMALDH1A1LMNATSHR | |
| SCHEMBL4770390 | 0.72 | ALDH1A1 (0.36) | HPGDPKMALDH1A1LMNATSHR | |
| SCHEMBL30509807 | 0.72 | PKM (0.36) | HPGDPKMALDH1A1LMNATSHR | |
| SCHEMBL7321280 | 0.72 | ALDH1A1 (0.36) | HPGDPKMALDH1A1LMNATSHR | |
| SCHEMBL20397085 | 0.72 | MGLL (0.60) | MGLLPKMALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200347078-A1 | HETEROCYCLYLMETHYLIDENE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 2020-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347078-A1 | HETEROCYCLYLMETHYLIDENE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS | GRM5, GRIK5, GRM2 | MGLL 1708/4885HPGD 956/4885PKM 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.