Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 5/20 | 0.51 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.51 |
| ▸ | MCTS1 | Q9ULC4 | 3/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CCKAR | P32238 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9349968 | 0.83 | PTGS2 (0.64) | PTGS2ALOX5PTGS1CYP1A2CYP3A4 | |
| SCHEMBL513268 | 0.78 | SLC16A3 (0.42) | SLC16A3SLC16A1MCTS1TSHRSMN1; SMN2 | |
| SCHEMBL20600256 | 0.77 | NPC1 (0.47) | SLC16A3SLC16A1MCTS1NPSR1SMN1; SMN2 | |
| SCHEMBL20600034 | 0.77 | MAPK14 (0.45) | SLC16A3SLC16A1MCTS1CYP1A2CYP3A4 | |
| SCHEMBL2226540 | 0.74 | SLC16A3 (0.56) | SLC16A3SLC16A1MCTS1SMN1; SMN2KDM4E | |
| SCHEMBL29915428 | 0.73 | SLC16A3 (0.48) | SLC16A3SLC16A1MCTS1CCKARTP53 | |
| SCHEMBL31130342 | 0.73 | SLC16A3 (0.65) | SLC16A3SLC16A1MCTS1 | |
| SCHEMBL6607342 | 0.71 | CYP1A2 (0.43) | NPBWR1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7995817 | 0.71 | MAPT (0.63) | CYP1A2CYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL23297331 | 0.71 | MAPT (0.72) | NPBWR1TSHRSMN1; SMN2KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | Recordati Industria Chimica e Farmacentica S.p.A. (IT) | 2022-09-13 | — | — | US | disclosed |
| US-20200347078-A1 | HETEROCYCLYLMETHYLIDENE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 2020-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347078-A1 | HETEROCYCLYLMETHYLIDENE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS | GRM5, GRIK5, GRM2 | SLC16A3 1146/4885SLC16A1 778/4885MCTS1 4563/4885 |
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | GRM5, GRIK5, GRM2 | SLC16A3 1146/4885SLC16A1 778/4885MCTS1 4563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.