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Sugi Predict / Compounds / SCHEMBL23297331

SCHEMBL23297331

SCHEMBL23297331

COc1ccc(-c2ccc(=O)n(Cc3ccc(Cl)cc3)n2)cc1

nearest known ligand 0.76

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.72
▸ SMN1; SMN2 Q16637 2/20 0.72
▸ MEN1 O00255 4/20 0.63
▸ KMT2A Q03164 4/20 0.63
▸ HDAC1 Q13547 2/20 0.59
▸ PDE4A P27815 1/20 0.56
▸ PDE4B Q07343 1/20 0.56
▸ PDE4C Q08493 1/20 0.56
▸ PDE4D Q08499 1/20 0.56
▸ TP53 P04637 2/20 0.55
▸ TSHR P16473 1/20 0.54
▸ KDM4E B2RXH2 1/20 0.54
▸ HSD17B10 Q99714 1/20 0.54
▸ NPBWR1 P48145 1/20 0.52
▸ POLB P06746 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23297238 1.00 MAPT (0.72) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL23297212 0.95 MAPT (0.79) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL23297284 0.89 MEN1 (0.60) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL23297307 0.88 MAPT (0.71) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL31409833 0.88 MAPT (0.71) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL4125055 0.88 MAPT (0.71) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL23297211 0.88 MAPT (0.71) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL23297266 0.88 MAPT (0.71) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL23297368 0.88 PDE4B (0.71) MAPTSMN1; SMN2MEN1KMT2AHDAC1
SCHEMBL3841611 0.88 MAPT (0.70) MAPTSMN1; SMN2MEN1KMT2AHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12240833-B2 Pyridazinone compounds and uses thereof EDGEWISE THERAPEUTICS, INC. (US) 2025-03-04 — — US disclosed
EP-3877367-B1 PYRIDAZINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS INC (US) 2024-05-22 — — EP disclosed
US-20230338375-A1 SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES EDGEWISE THERAPEUTICS, INC. 2023-10-26 — — US disclosed
US-20230338375-A1 SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES EDGEWISE THERAPEUTICS, INC. 2023-10-26 — — US disclosed
US-20230338375-A1 SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES EDGEWISE THERAPEUTICS, INC. 2023-10-26 — — US disclosed
US-20230048816-A1 PYRIDAZINONE COMPOUNDS AND USES THEREOF CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) 2023-02-16 — — US disclosed
US-11390606-B2 Pyridazinone compounds and uses thereof EDGEWISE THERAPECUTICS, INC. (US) 2022-07-19 — — US disclosed
WO-2021231630-A1 SUBSTITUTED PYRIDAZINONE FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES EDGEWISE THERAPEUTICS, INC. (US) 2021-11-18 — — WO disclosed
US-20210130327-A1 PYRIDAZINONE COMPOUNDS AND USES THEREOF CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) 2021-05-06 — — US disclosed
US-20210130327-A1 PYRIDAZINONE COMPOUNDS AND USES THEREOF CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) 2021-05-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230338375-A1 SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES IL6, MUSK, SMN1; SMN2 MAPT 1863/4885SMN1; SMN2 3/4885MEN1 4467/4885
US-12240833-B2 Pyridazinone compounds and uses thereof IL6, IL1B, IL1A MAPT 1810/4885SMN1; SMN2 9/4885MEN1 4368/4885
US-11390606-B2 Pyridazinone compounds and uses thereof IL6, IL1B, IL1A MAPT 1810/4885SMN1; SMN2 9/4885MEN1 4368/4885
US-20210130327-A1 PYRIDAZINONE COMPOUNDS AND USES THEREOF IL6, IL1B, IL1A MAPT 1810/4885SMN1; SMN2 9/4885MEN1 4368/4885
US-20230048816-A1 PYRIDAZINONE COMPOUNDS AND USES THEREOF IL6, IL1B, IL1A MAPT 1810/4885SMN1; SMN2 9/4885MEN1 4368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.