SCHEMBL226137

SCHEMBL226137

Oc1cc(C(F)(F)F)ccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
TSHR P16473 2/20 0.50
CYP3A4 P08684 1/20 0.50
HSD17B10 Q99714 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
PDE2A O00408 1/20 0.48
CHRNA7 P36544 1/20 0.47
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
LMNA P02545 1/20 0.45
GAA P10253 1/20 0.44
MAPT P10636 2/20 0.42
JAK2 O60674 1/20 0.41
JAK1 P23458 1/20 0.41
TYK2 P29597 1/20 0.41
KIF11 P52732 1/20 0.41
KDM4E B2RXH2 1/20 0.41
NQO2 P16083 1/20 0.41
ATM Q13315 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29143042 0.98 ALDH1A1 (0.48) ALDH1A1TSHRCYP3A4HSD17B10TDP1
Ethylene Glycol SCHEMBL29238126 0.92 ALDH1A1 (0.43) ALDH1A1TSHRCYP3A4HSD17B10TDP1
Trifluoromethanesulfonic Acid SCHEMBL6584577 0.87 MEN1 (0.44) ALDH1A1TSHRCYP3A4HSD17B10TDP1
SCHEMBL225921 0.82 PDE2A (0.53) ALDH1A1TSHRHSD17B10PDE2ACHRNA7
SCHEMBL29430111 0.82 PDE2A (0.53) ALDH1A1TSHRHSD17B10PDE2ACHRNA7
Water SCHEMBL29058831 0.80 PDE2A (0.52) ALDH1A1TSHRHSD17B10PDE2ACHRNA7
Potassium SCHEMBL30520491 0.80 PDE2A (0.52) ALDH1A1TSHRHSD17B10PDE2ACHRNA7
SCHEMBL28426979 0.80 PDE2A (0.52) ALDH1A1TSHRHSD17B10PDE2ACHRNA7
SCHEMBL27487833 0.80 PDE2A (0.52) ALDH1A1TSHRHSD17B10PDE2ACHRNA7
Water SCHEMBL30585009 0.78 PDE2A (0.50) ALDH1A1TSHRHSD17B10PDE2ACHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 295 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118085486-A Type II porous liquid containing high-concentration coordination cage and preparation method and application thereof 南京工业大学 2024-05-28 CN claimed
CN-117447328-A Clean production method of oxyfluorfen 首建科技有限公司 2024-01-26 CN claimed
CN-116655456-A Method for efficiently purifying and separating 2-chloro-4-trifluoromethyl phenol 上虞颖泰精细化工有限公司 2023-08-29 CN claimed
US-6989052-B1 Phase change ink printing process XEROX CORPORATION (US) 2006-01-24 US claimed
US-20060004123-A1 PHASE CHANGE INK PRINTING PROCESS XEROX CORPORATION 2006-01-05 US claimed
US-5354495-A Homo- or copolymerizable through ethylenic unsaturation NIPPON PAINT CO., LTD. (JP) 1994-10-11 US claimed
EP-0177122-B1 ACRYLAMIDE DERIVATIVES Nippon Paint Co., Ltd. (JP) 1992-04-01 EP claimed
JP-57149269-A None JP disclosed
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-01-22 US disclosed
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors HOFFMANN-LA ROCHE INC. (US) 2025-04-22 US disclosed
CN-119118983-A Xanthone compound and intermediate thereof, preparation method, pharmaceutical composition and application 上海药坦药物研究开发有限公司 2024-12-13 CN disclosed
EP-4474017-A2 NEW HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2024-12-11 EP disclosed
CN-116554006-B Method for efficiently recycling oxyfluorfen byproduct 2-chloro-4-trifluoromethylphenol potassium salt and application 上虞颖泰精细化工有限公司 2024-10-18 CN disclosed
US-4935413-A ELASTICITY, ADHESION AND DISPERSIBILITY NIPPON PAINT CO., LTD. (JP) 1990-06-19 US disclosed
EP-0304725-A1 Process for the preparation of nitro-diphenyl(thio) ethers BAYER AG (DE) 1989-03-01 EP disclosed
EP-0207621-A2 Functional polymers and their production Nippon Paint Co., Ltd. (JP) 1987-01-07 EP disclosed
EP-0177122-A2 Acrylamide derivatives Nippon Paint Co., Ltd. (JP) 1986-04-09 EP disclosed
US-4504689-A Process for the preparation of phenates substituted by halogen groups or of the corresponding phenols RHONE-POULENC AGROCHIMIE (FR) 1985-03-12 US disclosed
JP-S57149269-A PHENOXYPYRIDINE COMPOUND ISHIHARA SANGYO KAISHA LTD 1982-09-14 JP disclosed
US-4013817-A HALOGENATED AROMATIC HYDROCARBON BRIDGESTONE TIRE COMPANY LIMITED (JA) 1977-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LIPA, LPL ALDH1A1 1338/4885TSHR 1083/4885CYP3A4 784/4885
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors LIPC, LPL, MGLL ALDH1A1 525/4885TSHR 1624/4885CYP3A4 497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.