Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MFN2 | O95140 | 1/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27245326 | 1.00 | MFN2 (1.00) | MFN2EPHX2EPHX1HPGDNPC1 | |
| SCHEMBL22289758 | 1.00 | MFN2 (1.00) | MFN2EPHX2EPHX1HPGDNPC1 | |
| SCHEMBL27245327 | 1.00 | MFN2 (1.00) | MFN2EPHX2EPHX1HPGDNPC1 | |
| SCHEMBL22315339 | 0.92 | MFN2 (0.86) | MFN2EPHX2EPHX1HPGDNPC1 | |
| SCHEMBL23766479 | 0.89 | MFN2 (0.80) | MFN2EPHX2EPHX1HPGDNPC1 | |
| SCHEMBL30233690 | 0.81 | MFN2 (0.69) | MFN2EPHX2EPHX1HPGDTSHR | |
| SCHEMBL27245325 | 0.80 | MFN2 (0.67) | MFN2EPHX2EPHX1HPGDTSHR | |
| SCHEMBL27028451 | 0.80 | MFN2 (0.67) | MFN2EPHX2EPHX1HPGDTSHR | |
| SCHEMBL27245328 | 0.79 | MFN2 (0.65) | MFN2EPHX2EPHX1HPGDNPC1 | |
| SCHEMBL27245324 | 0.79 | MFN2 (0.65) | MFN2EPHX2EPHX1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240199534-A1 | CYCLOPROPANE ANALOGUES OF N-(TRANS-4-HYDROXYCYCLOHEXYL)-6-PHENYLHEXANAMIDE AND RELATED COMPOUNDS | DORN, GERALD W., II, DR. | 2024-06-20 | — | — | US | disclosed |
| CN-117377652-A | Cyclopropane analogues of N- (trans-4-hydroxycyclohexyl) -6-phenylhexanamide and related compounds | 线粒体情感状态公司 | 2024-01-09 | — | — | CN | disclosed |
| US-20210251925-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2021-08-19 | — | — | US | disclosed |
| US-11083699-B2 | Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof | MITOCHONDRIA EMOTION, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-20200345668-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2020-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200345668-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, TFB2M, HADHA | MFN2 1/4885EPHX2 3873/4885EPHX1 3536/4885 |
| US-11083699-B2 | Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof | MFN2, TFB2M, HADHA | MFN2 1/4885EPHX2 3873/4885EPHX1 3536/4885 |
| US-20240199534-A1 | CYCLOPROPANE ANALOGUES OF N-(TRANS-4-HYDROXYCYCLOHEXYL)-6-PHENYLHEXANAMIDE AND RELATED COMPOUNDS | HAGH, HADHA, NLN | MFN2 135/4885EPHX2 2503/4885EPHX1 2458/4885 |
| US-20210251925-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, TFB2M, HADHA | MFN2 1/4885EPHX2 3873/4885EPHX1 3536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.