Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22624780 | 0.95 | LMNA (0.50) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL8320641 | 0.83 | LMNA (0.57) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL22624685 | 0.81 | SMN1; SMN2 (0.62) | LMNAHTTMAPTHSD17B10RAB9A | |
| SCHEMBL22624684 | 0.80 | CDK1 (0.57) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL8319913 | 0.78 | LMNA (0.54) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL2093580 | 0.77 | LMNA (0.60) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL10476873 | 0.77 | RAB9A (0.80) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL12116138 | 0.75 | LMNA (0.61) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL12116162 | 0.74 | MEN1 (0.55) | LMNAHTTMAPTHSD17B10NPC1 | |
| SCHEMBL7383453 | 0.74 | MAPT (0.72) | LMNAHTTMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020223609-A1 | METHODS AND COMPOSITIONS FOR SENSITIZING CANCER CELLS TO DRUG-INDUCED APOPTOSIS | NEW YORK UNIVERSITY (US) | 2020-11-05 | — | — | WO | disclosed |