Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CBS | P35520 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319928 | 0.84 | RAB9A (0.63) | LMNAMAPTMEN1KMT2ANPSR1 | |
| SCHEMBL22624686 | 0.83 | LMNA (0.52) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL8319913 | 0.80 | LMNA (0.54) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL22624780 | 0.79 | LMNA (0.50) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL10476873 | 0.79 | RAB9A (0.80) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL2093580 | 0.79 | LMNA (0.60) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL12116138 | 0.77 | LMNA (0.61) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL12116162 | 0.76 | MEN1 (0.55) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL7383453 | 0.76 | MAPT (0.72) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL10476875 | 0.76 | HPGD (0.66) | LMNAHTTMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977170-A | HIGH DENISTY LIPOPROTEINS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1998057927-A1 | ELEVATION OF HDL CHOLESTEROL BY 4-[(AMINOTHIOXOMETHYL)HYDRAZONO]-4-ARYLBUTYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |