Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | ARG1 | P05089 | 1/20 | 0.34 |
| ▸ | ARG2 | P78540 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | BLM | P54132 | 3/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286756 | 0.86 | NOS2 (0.38) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL24919549 | 0.86 | NOS2 (0.38) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL19628287 | 0.84 | CYP2D6 (0.46) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL19628285 | 0.84 | CYP2D6 (0.46) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL19628286 | 0.84 | CYP2D6 (0.46) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL12421053 | 0.83 | NOS2 (0.36) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL21955443 | 0.81 | ARG1 (0.36) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL16572561 | 0.79 | — | — | |
| SCHEMBL2781165 | 0.79 | ARG1 (0.53) | NOS2NOS1NOS3ARG1ARG2 | |
| SCHEMBL25788608 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102507-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-08 | — | — | WO | disclosed |
| EP-3733693-A1 | IL-2 VARIANT | Kyowa Kirin Co., Ltd. (JP) | 2020-11-04 | — | — | EP | disclosed |