Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627582 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TDP1KMT2AEPHX2 | |
| SCHEMBL22956133 | 0.87 | TDP1 (0.56) | ALDH1A1GRIN1GRIN2BTDP1GBA1 | |
| SCHEMBL22627852 | 0.86 | TRPV1 (0.43) | ALDH1A1GRIN1GRIN2BTDP1GBA1 | |
| SCHEMBL25803379 | 0.83 | TDP1 (0.42) | ALDH1A1GRIN1GRIN2BTDP1GBA1 | |
| SCHEMBL22628294 | 0.81 | RXFP1 (0.57) | ALDH1A1GRIN1GRIN2BKMT2ATAOK1 | |
| SCHEMBL25796969 | 0.81 | TDP1 (0.43) | ALDH1A1TDP1KMT2ARXFP1HPGD | |
| SCHEMBL22956490 | 0.81 | HPGD (0.40) | TDP1KMT2ASMN1; SMN2EPHX2HPGD | |
| SCHEMBL25808242 | 0.80 | GRIN1 (0.47) | ALDH1A1GRIN1GRIN2BGBA1KMT2A | |
| SCHEMBL22627559 | 0.80 | ATF4 (0.41) | ALDH1A1TDP1EPHX2 | |
| SCHEMBL25799259 | 0.80 | ALDH1A1 (0.40) | ALDH1A1TDP1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200345727-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200345727-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885GRIN1 1690/4885GRIN2B 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.