⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22633653 | 0.77 | — | — | |
| SCHEMBL24015502 | 0.71 | SLC10A1 (0.31) | — | |
| SCHEMBL22395868 | 0.70 | — | — | |
| SCHEMBL21843744 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL19900818 | 0.62 | APLNR (0.31) | — | |
| SCHEMBL22395844 | 0.62 | ALDH1A1 (0.31) | — | |
| SCHEMBL22363155 | 0.60 | — | — | |
| SCHEMBL16914106 | 0.59 | — | — | |
| SCHEMBL22506477 | 0.58 | APLNR (0.35) | — | |
| SCHEMBL22395766 | 0.58 | DGAT1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11267825-B2 | Highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis B virus (HBV) | AICURIS GMBH & CO. KG (DE) | 2022-03-08 | — | — | US | disclosed |
| US-20220009945-A1 | NOVEL UREA 6,7-DIHYDRO-4H-THIAZOLE[5,4-C]PYRIDINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2022-01-13 | — | — | US | disclosed |
| CN-113039187-A | Urea 6, 7-dihydro-4H-thiazolo [5,4-c ] pyridine active agents against hepatitis b virus HBV | 艾库里斯有限及两合公司 | 2021-06-25 | — | — | CN | disclosed |
| US-20200354379-A1 | NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-12 | — | — | US | disclosed |
| US-20200354379-A1 | NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-12 | — | — | US | disclosed |
| CN-111448199-A | Novel highly active amino-thiazole-substituted indole-2-carboxamides having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2020-07-24 | — | — | CN | disclosed |