Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20517749 | 0.92 | TRPV4 (0.39) | TRPV4KHKPGK1VCAM1MEN1 | |
| SCHEMBL15407630 | 0.83 | GAA (0.44) | TRPV4KHKVCAM1MEN1MAPT | |
| SCHEMBL9460722 | 0.82 | MEN1 (0.41) | KHKMEN1MAPTKMT2AGAA | |
| SCHEMBL1291792 | 0.82 | GAA (0.46) | TRPV4KHKPGK1VCAM1MEN1 | |
| SCHEMBL31314338 | 0.80 | GAA (0.50) | TRPV4KHKPGK1VCAM1MEN1 | |
| SCHEMBL25235179 | 0.76 | TRPV4 (0.43) | TRPV4PGK1VCAM1MEN1KMT2A | |
| SCHEMBL7073779 | 0.76 | GAA (0.57) | TRPV4KHKPGK1VCAM1MEN1 | |
| SCHEMBL30498666 | 0.76 | GAA (0.57) | TRPV4KHKPGK1VCAM1MEN1 | |
| SCHEMBL22637057 | 0.75 | TRPV4 (0.45) | TRPV4KHKMEN1MAPTKMT2A | |
| SCHEMBL2479059 | 0.75 | ALDH1A1 (0.46) | TRPV4KHKPGK1VCAM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12377084-B2 | ERAP1 modulators | Grey Wolf Therapeutics Limited (GB) | 2025-08-05 | — | — | US | disclosed |
| US-20240366595-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| US-12023333-B2 | Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators | Grey Wolf Therapeutics Limited (GB) | 2024-07-02 | — | — | US | disclosed |
| US-20230000851-A1 | ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2023-01-05 | — | — | US | disclosed |
| US-20220347176-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-11-03 | — | — | US | disclosed |
| EP-4058429-A1 | ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-09-21 | — | — | EP | disclosed |
| EP-3966196-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-03-16 | — | — | EP | disclosed |
| WO-2021094763-A1 | ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2021-05-20 | — | — | WO | disclosed |
| WO-2020225569-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240366595-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | CHP1, ERAP1, QSOX1 | TRPV4 4394/4885KHK 2697/4885PGK1 3616/4885 |
| US-20220347176-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | ERAP1, CHP1, QSOX1 | TRPV4 4371/4885KHK 2879/4885PGK1 3363/4885 |
| US-12377084-B2 | ERAP1 modulators | ERAP1, NR1I3, HRH4 | TRPV4 1187/4885KHK 3514/4885PGK1 3793/4885 |
| US-12023333-B2 | Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators | ERAP1, CHP1, QSOX1 | TRPV4 4279/4885KHK 2717/4885PGK1 3500/4885 |
| US-20230000851-A1 | ERAP1 MODULATORS | ERAP1, NR1I3, HRH4 | TRPV4 1187/4885KHK 3514/4885PGK1 3793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.