Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Cellobiose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS8 | O00214 | 2/20 | 0.49 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.49 |
| ▸ | LGALS4 | P56470 | 2/20 | 0.49 |
| ▸ | IGF2R | P11717 | 2/20 | 0.45 |
| ▸ | AMY2A | P04746 | 2/20 | 0.43 |
| ▸ | FGF1 | P05230 | 1/20 | 0.42 |
| ▸ | FGF2 | P09038 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 8/20 | 0.41 |
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA9 | Q16790 | 8/20 | 0.41 |
| ▸ | CA12 | O43570 | 7/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cellobiose SCHEMBL5310426 | 0.92 | LGALS8 (0.55) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Cellobiose SCHEMBL16460079 | 0.92 | LGALS8 (0.55) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Cellobiose SCHEMBL2787564 | 0.92 | LGALS8 (0.55) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Maltose SCHEMBL8994870 | 0.91 | LGALS8 (0.53) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Cellobiose SCHEMBL3931903 | 0.91 | LGALS8 (0.53) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Cellobiose SCHEMBL11230654 | 0.89 | LGALS8 (0.49) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Cellobiose SCHEMBL29818287 | 0.88 | LGALS8 (0.53) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Cellobiose SCHEMBL4576482 | 0.87 | LGALS8 (0.52) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Cellobiose SCHEMBL16346065 | 0.86 | LGALS3 (0.51) | LGALS8LGALS3LGALS4IGF2RAMY2A | |
| Maltose SCHEMBL8343753 | 0.84 | LGALS8 (0.54) | LGALS8LGALS3LGALS4IGF2RAMY2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227337-A1 | PRODRUG COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-11-12 | — | — | WO | disclosed |