Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KCNJ1 | P48048 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22640138 | 0.77 | NPC1 (0.57) | ALDH1A1KCNJ1HTTTP53THRB | |
| SCHEMBL22640139 | 0.77 | NPC1 (0.57) | ALDH1A1KCNJ1HTTTP53THRB | |
| SCHEMBL11963336 | 0.73 | MEP1B (0.62) | ALDH1A1HTTKMT2ATP53L3MBTL1 | |
| SCHEMBL22640000 | 0.72 | MEN1 (0.54) | ALDH1A1KCNJ1HTTKMT2ATHRB | |
| SCHEMBL18498694 | 0.72 | MAPT (0.59) | KMT2ATP53THRBMAPTPOLB | |
| SCHEMBL11575607 | 0.69 | MEP1B (0.61) | ALDH1A1HTTKMT2ATP53L3MBTL1 | |
| SCHEMBL16261204 | 0.68 | ALDH1A1 (0.54) | ALDH1A1HTTKMT2AMEP1BSMN1; SMN2 | |
| SCHEMBL22639780 | 0.68 | KDM1A (0.48) | ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL17101675 | 0.68 | MEP1B (0.52) | ALDH1A1HTTKMT2ATP53L3MBTL1 | |
| SCHEMBL14934294 | 0.67 | ALDH1A1 (0.57) | ALDH1A1HTTKMT2AMEP1BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2020-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | VIM, MATR3, TP53 | ALDH1A1 1636/4885KCNJ1 4860/4885HTT 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.