Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22645322 | 1.00 | ALDH1A1 (0.57) | ALDH1A1NPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL22645320 | 1.00 | ALDH1A1 (0.57) | ALDH1A1NPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL22662526 | 1.00 | ALDH1A1 (0.57) | ALDH1A1NPSR1CYP1A2CYP3A4CYP2C9 | |
| N-Sec-Butylcinnamamide SCHEMBL24740108 | 0.83 | ALDH1A1 (0.69) | ALDH1A1NPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL22645401 | 0.81 | ALDH1A1 (0.62) | ALDH1A1NPSR1TDP1HTTMMP1 | |
| SCHEMBL22645341 | 0.79 | ALDH1A1 (0.59) | ALDH1A1NPSR1HTTMMP1MMP2 | |
| SCHEMBL22645465 | 0.77 | HDAC3 (0.59) | ALDH1A1NPSR1CYP1A2CYP2C9TDP1 | |
| SCHEMBL22645466 | 0.77 | HDAC3 (0.59) | ALDH1A1NPSR1CYP1A2CYP2C9TDP1 | |
| SCHEMBL22645468 | 0.77 | HDAC3 (0.59) | ALDH1A1NPSR1CYP1A2CYP2C9TDP1 | |
| SCHEMBL22645300 | 0.77 | EGFR (0.64) | ALDH1A1NPSR1HTTMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11312694-B2 | Method for making propenamide compound | KING ABDULAZIZ UNIVERSITY (SA) | 2022-04-26 | — | — | US | disclosed |
| US-20220033368-A1 | METHOD FOR MAKING PROPENAMIDE COMPOUND | KING ABDULAZIZ UNIVERSITY (SA) | 2022-02-03 | — | — | US | disclosed |
| US-20220009896-A1 | METHOD OF TREATING COLORECTAL CANCER | KING ABDULAZIZ UNIVERSITY (SA) | 2022-01-13 | — | — | US | disclosed |
| US-11214556-B1 | Method of treating colorectal cancer | KING ABDULAZIZ UNIVERSITY (SA) | 2022-01-04 | — | — | US | disclosed |
| US-11155528-B2 | Bis-propenamide compounds and methods of treating cancer | KING ABDULAZIZ UNIVERSITY (SA) | 2021-10-26 | — | — | US | disclosed |
| US-20210122721-A1 | BIS-PROPENAMIDE COMPOUNDS AND METHODS OF TREATING CANCER | KING ABDULAZIZ UNIVERSITY (SA) | 2021-04-29 | — | — | US | disclosed |
| US-10836736-B1 | Pharmaceutical composition with cytotoxic activity on colorectal cancer cells | KING ABDULAZIZ UNIVERSITY (SA) | 2020-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836736-B1 | Pharmaceutical composition with cytotoxic activity on colorectal cancer cells | APC, DCK, ABCB1 | ALDH1A1 695/4885NPSR1 3962/4885CYP1A2 117/4885 |
| US-20210122721-A1 | BIS-PROPENAMIDE COMPOUNDS AND METHODS OF TREATING CANCER | APC, CCNE1, CCNI | ALDH1A1 392/4885NPSR1 1871/4885CYP1A2 141/4885 |
| US-20220009896-A1 | METHOD OF TREATING COLORECTAL CANCER | APC, SLC10A2, FOLR1 | ALDH1A1 350/4885NPSR1 3434/4885CYP1A2 53/4885 |
| US-11312694-B2 | Method for making propenamide compound | APC, CYP2C19, PKD1 | ALDH1A1 353/4885NPSR1 1752/4885CYP1A2 94/4885 |
| US-20220033368-A1 | METHOD FOR MAKING PROPENAMIDE COMPOUND | APC, CYP2C19, PKD1 | ALDH1A1 353/4885NPSR1 1752/4885CYP1A2 94/4885 |
| US-11155528-B2 | Bis-propenamide compounds and methods of treating cancer | APC, CCNE1, CCNI | ALDH1A1 392/4885NPSR1 1871/4885CYP1A2 141/4885 |
| US-11214556-B1 | Method of treating colorectal cancer | APC, SLC10A2, FOLR1 | ALDH1A1 350/4885NPSR1 3434/4885CYP1A2 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.