Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.51 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.51 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.51 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22645341 | 0.93 | ALDH1A1 (0.59) | MAPTKMT2AALDH1A1NPSR1PLAAT3 | |
| SCHEMBL22645560 | 0.90 | KCNA3 (0.51) | MAPTNLRP3KMT2AMEN1CYP1A2 | |
| SCHEMBL22645524 | 0.89 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL22645393 | 0.88 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL22645390 | 0.88 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL22662495 | 0.88 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL22645349 | 0.88 | MAPT (0.55) | MAPTNLRP3KMT2AMEN1CYP1A2 | |
| SCHEMBL22645443 | 0.86 | KMT2A (0.57) | MAPTKMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL22645382 | 0.86 | ALDH1A1 (0.51) | MAPTKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL22645300 | 0.85 | EGFR (0.64) | MAPTKMT2AALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11312694-B2 | Method for making propenamide compound | KING ABDULAZIZ UNIVERSITY (SA) | 2022-04-26 | — | — | US | disclosed |
| US-11312694-B2 | Method for making propenamide compound | KING ABDULAZIZ UNIVERSITY (SA) | 2022-04-26 | — | — | US | disclosed |
| US-20220033368-A1 | METHOD FOR MAKING PROPENAMIDE COMPOUND | KING ABDULAZIZ UNIVERSITY (SA) | 2022-02-03 | — | — | US | disclosed |
| US-20220033368-A1 | METHOD FOR MAKING PROPENAMIDE COMPOUND | KING ABDULAZIZ UNIVERSITY (SA) | 2022-02-03 | — | — | US | disclosed |
| US-20220009896-A1 | METHOD OF TREATING COLORECTAL CANCER | KING ABDULAZIZ UNIVERSITY (SA) | 2022-01-13 | — | — | US | disclosed |
| US-20220009896-A1 | METHOD OF TREATING COLORECTAL CANCER | KING ABDULAZIZ UNIVERSITY (SA) | 2022-01-13 | — | — | US | disclosed |
| US-11214556-B1 | Method of treating colorectal cancer | KING ABDULAZIZ UNIVERSITY (SA) | 2022-01-04 | — | — | US | disclosed |
| US-11214556-B1 | Method of treating colorectal cancer | KING ABDULAZIZ UNIVERSITY (SA) | 2022-01-04 | — | — | US | disclosed |
| US-11155528-B2 | Bis-propenamide compounds and methods of treating cancer | KING ABDULAZIZ UNIVERSITY (SA) | 2021-10-26 | — | — | US | disclosed |
| US-11155528-B2 | Bis-propenamide compounds and methods of treating cancer | KING ABDULAZIZ UNIVERSITY (SA) | 2021-10-26 | — | — | US | disclosed |
| US-20210122721-A1 | BIS-PROPENAMIDE COMPOUNDS AND METHODS OF TREATING CANCER | KING ABDULAZIZ UNIVERSITY (SA) | 2021-04-29 | — | — | US | disclosed |
| US-20210122721-A1 | BIS-PROPENAMIDE COMPOUNDS AND METHODS OF TREATING CANCER | KING ABDULAZIZ UNIVERSITY (SA) | 2021-04-29 | — | — | US | disclosed |
| US-10836736-B1 | Pharmaceutical composition with cytotoxic activity on colorectal cancer cells | KING ABDULAZIZ UNIVERSITY (SA) | 2020-11-17 | — | — | US | disclosed |
| US-10836736-B1 | Pharmaceutical composition with cytotoxic activity on colorectal cancer cells | KING ABDULAZIZ UNIVERSITY (SA) | 2020-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836736-B1 | Pharmaceutical composition with cytotoxic activity on colorectal cancer cells | APC, DCK, ABCB1 | MAPT 4583/4885NLRP3 4334/4885KMT2A 3367/4885 |
| US-20210122721-A1 | BIS-PROPENAMIDE COMPOUNDS AND METHODS OF TREATING CANCER | APC, CCNE1, CCNI | MAPT 3640/4885NLRP3 4789/4885KMT2A 2626/4885 |
| US-20220009896-A1 | METHOD OF TREATING COLORECTAL CANCER | APC, SLC10A2, FOLR1 | MAPT 4626/4885NLRP3 4512/4885KMT2A 2411/4885 |
| US-11312694-B2 | Method for making propenamide compound | APC, CYP2C19, PKD1 | MAPT 3739/4885NLRP3 4526/4885KMT2A 2433/4885 |
| US-20220033368-A1 | METHOD FOR MAKING PROPENAMIDE COMPOUND | APC, CYP2C19, PKD1 | MAPT 3739/4885NLRP3 4526/4885KMT2A 2433/4885 |
| US-11155528-B2 | Bis-propenamide compounds and methods of treating cancer | APC, CCNE1, CCNI | MAPT 3640/4885NLRP3 4789/4885KMT2A 2626/4885 |
| US-11214556-B1 | Method of treating colorectal cancer | APC, SLC10A2, FOLR1 | MAPT 4626/4885NLRP3 4512/4885KMT2A 2411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.