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Sugi Predict / Compounds / SCHEMBL22647455

SCHEMBL22647455

SCHEMBL22647455

CC(C)(C)OC(=O)[C@H](CC(N)=O)NC(=O)N(Cc1ccccc1)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 1/20 0.41
▸ RAB9A P51151 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ HCRTR1 O43613 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ BACE1 P56817 9/20 0.38
▸ PSEN1 P49768 2/20 0.38
▸ PSEN2 P49810 2/20 0.38
▸ APH1B Q8WW43 2/20 0.38
▸ NCSTN Q92542 2/20 0.38
▸ APH1A Q96BI3 2/20 0.38
▸ PSENEN Q9NZ42 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ AKT1 P31749 1/20 0.37
▸ ITGA4 P13612 1/20 0.37
▸ ITGB7 P26010 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29471100 1.00 APP (0.41) APPRAB9AMEN1NPC1KMT2A
SCHEMBL22649244 0.90 HCRTR1 (0.48) HCRTR1PSEN1PSEN2APH1BNCSTN
SCHEMBL22651913 0.90 L3MBTL1 (0.41) RAB9AMEN1NPC1KMT2AL3MBTL1
SCHEMBL22649160 0.88 MEN1 (0.39) RAB9AMEN1NPC1KMT2AHCRTR1
SCHEMBL22647598 0.88 PSEN1 (0.49) MEN1KMT2APSEN1PSEN2APH1B
SCHEMBL22647600 0.88 PSEN1 (0.49) MEN1KMT2APSEN1PSEN2APH1B
SCHEMBL29405291 0.88 PSEN1 (0.49) MEN1KMT2APSEN1PSEN2APH1B
SCHEMBL22634276 0.85 ALDH1A1 (0.48) RAB9AMEN1NPC1KMT2AL3MBTL1
SCHEMBL22634274 0.85 ALDH1A1 (0.48) RAB9AMEN1NPC1KMT2AL3MBTL1
SCHEMBL22647626 0.85 PPARA (0.41) APPRAB9AMEN1NPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11414405-B2 Compounds for use in synthesis of peptidomimetics THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2022-08-16 — — US disclosed
US-20210130331-A1 COMPOUNDS FOR USE IN SYNTHESIS OF PEPTIDOMIMETICS THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2021-05-06 — — US disclosed
US-10919882-B2 Compounds for use in synthesis of peptidomimetics THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2021-02-16 — — US disclosed
US-20200354344-A1 COMPOUNDS FOR USE IN SYNTHESIS OF PEPTIDOMIMETICS THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2020-11-12 — — US disclosed
WO-2020227594-A1 COMPOUNDS FOR USE IN SYNTHESIS OF PEPTIDOMIMETICS THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2020-11-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11414405-B2 Compounds for use in synthesis of peptidomimetics DNPEP, NPEPPS, PAM APP 1061/4885RAB9A 4849/4885MEN1 693/4885
US-20210130331-A1 COMPOUNDS FOR USE IN SYNTHESIS OF PEPTIDOMIMETICS DNPEP, NPEPPS, PAM APP 1061/4885RAB9A 4849/4885MEN1 693/4885
US-10919882-B2 Compounds for use in synthesis of peptidomimetics DNPEP, NPEPPS, PAM APP 1061/4885RAB9A 4849/4885MEN1 693/4885
US-20200354344-A1 COMPOUNDS FOR USE IN SYNTHESIS OF PEPTIDOMIMETICS DNPEP, NPEPPS, PAM APP 1061/4885RAB9A 4849/4885MEN1 693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.