Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SLC7A11 | Q9UPY5 | 2/20 | 0.42 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222213 | 0.84 | METAP2 (0.68) | METAP2CYP1A2CYP2C9ALDH1A1HPGD | |
| SCHEMBL4578324 | 0.77 | HNF4A (0.54) | HNF4AALDH1A1AKR1C3AKR1C2MCL1 | |
| SCHEMBL22650200 | 0.77 | MEN1 (0.47) | HNF4AALDH1A1HSD17B10KDM4EKMT2A | |
| SCHEMBL23200283 | 0.75 | METAP2 (0.67) | METAP2CYP1A2CYP2C9HTTTDP1 | |
| SCHEMBL7556102 | 0.74 | ACLY (0.62) | METAP2CYP2C9ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30100431 | 0.73 | ACLY (0.66) | METAP2ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL221627 | 0.73 | KMT2A (0.49) | METAP2CYP2C9ALDH1A1HPGDHSD17B10 | |
| SCHEMBL219920 | 0.73 | ACLY (0.66) | METAP2ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL31046886 | 0.73 | METAP2 (0.53) | METAP2ALDH1A1KDM4ENEU3KMT2A | |
| SCHEMBL221687 | 0.73 | METAP2 (0.53) | METAP2ALDH1A1KDM4ENEU3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020225330-A1 | DHODH INHIBITORS AND THEIR USE AS ANTIVIRAL AGENTS | UNIVERSITÄT HAMBURG (DE) | 2020-11-12 | — | — | WO | disclosed |