Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650591 | 0.91 | CDK6 (0.48) | JAK2CDK2KCNH2CSF1RJAK1 | |
| SCHEMBL22650487 | 0.91 | CDK4 (0.42) | NTRK1JAK2CDK2KCNH2CSF1R | |
| SCHEMBL22650396 | 0.91 | CDK6 (0.47) | JAK2CDK2CSF1RJAK1JAK3 | |
| SCHEMBL22650406 | 0.88 | CDK6 (0.44) | JAK2CDK2CSF1RCDK4CCNA2 | |
| SCHEMBL22650922 | 0.80 | F10 (0.38) | NTRK1JAK2JAK1JAK3 | |
| SCHEMBL22650475 | 0.80 | CDK6 (0.58) | CDK2KCNH2CSF1RCDK4CCNA2 | |
| SCHEMBL22650476 | 0.80 | CDK6 (0.48) | NTRK1PTGS2CDK2KCNH2CSF1R | |
| SCHEMBL22650852 | 0.79 | CDK2 (0.59) | CDK2CDK4CCNA2CDK6 | |
| SCHEMBL22650482 | 0.79 | CDK1 (0.59) | JAK2PTGS2CDK2JAK1CDK4 | |
| SCHEMBL31693685 | 0.78 | CDK4 (0.58) | NTRK1JAK2PTGS2CDK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |