Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650401 | 0.91 | NTRK1 (0.46) | CDK4CDK6CSF1RJAK2NTRK1 | |
| SCHEMBL22650922 | 0.90 | F10 (0.38) | F10JAK2NTRK1LRRK2MTOR | |
| SCHEMBL22650591 | 0.89 | CDK6 (0.48) | CDK4CDK6CSF1RJAK2CDK2 | |
| SCHEMBL22650396 | 0.86 | CDK6 (0.47) | CDK4CDK6CSF1RJAK2CDK2 | |
| SCHEMBL22650406 | 0.83 | CDK6 (0.44) | CDK4CDK6CSF1RF10JAK2 | |
| SCHEMBL22650475 | 0.79 | CDK6 (0.58) | CDK4CDK6CSF1RCDK2PIK3CD | |
| SCHEMBL22650476 | 0.79 | CDK6 (0.48) | CDK4CDK6CSF1RNTRK1CDK2 | |
| SCHEMBL22650945 | 0.77 | CDK6 (0.60) | CDK4CDK6CSF1RCDK2PIK3CD | |
| SCHEMBL22650601 | 0.77 | CDK6 (0.48) | CDK4CDK6CDK2CCNA2CDK9 | |
| SCHEMBL22650846 | 0.76 | CDK4 (0.42) | CDK4CDK6JAK2CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |