Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650487 | 0.90 | CDK4 (0.42) | F10TYK2EGFRJAK2JAK3 | |
| SCHEMBL22650846 | 0.87 | CDK4 (0.42) | TYK2JAK2JAK3JAK1 | |
| SCHEMBL22650524 | 0.87 | CDK6 (0.38) | F10EGFR | |
| SCHEMBL22650715 | 0.85 | CDK6 (0.35) | EGFRJAK2MAP3K14MAPK8 | |
| SCHEMBL22650597 | 0.84 | EGFR (0.37) | EGFRJAK2JAK3JAK1MAPK8 | |
| SCHEMBL22650433 | 0.83 | EGFR (0.36) | EGFRMAPK8 | |
| SCHEMBL22650519 | 0.83 | EGFR (0.36) | EGFRMAPK8 | |
| SCHEMBL22650427 | 0.82 | EGFR (0.36) | EGFRJAK2JAK3 | |
| SCHEMBL22650401 | 0.80 | NTRK1 (0.46) | JAK2JAK3JAK1NTRK1 | |
| SCHEMBL22650591 | 0.79 | CDK6 (0.48) | TYK2JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |