Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 8/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650457 | 0.88 | CDK4 (0.40) | CDK4CCND3CDK6IKBKETBK1 | |
| SCHEMBL22650597 | 0.88 | EGFR (0.37) | EGFRMAPK1MAPK3CDK4MAPK8 | |
| SCHEMBL22650434 | 0.84 | JAK2 (0.36) | CDK4 | |
| SCHEMBL22650922 | 0.83 | F10 (0.38) | EGFRMAPK8 | |
| SCHEMBL22650524 | 0.83 | CDK6 (0.38) | EGFRMAPK1MAPK3CDK4CCND3 | |
| SCHEMBL22650760 | 0.82 | CDK4 (0.39) | CDK4CCND3CDK6GSK3B | |
| SCHEMBL22650519 | 0.82 | EGFR (0.36) | EGFRMAPK1MAPK3CDK4CCND3 | |
| SCHEMBL22650715 | 0.81 | CDK6 (0.35) | EGFRMAPK1MAPK3CDK4CCND3 | |
| SCHEMBL22650427 | 0.81 | EGFR (0.36) | EGFRMAPK1MAPK3CDK4CCND3 | |
| SCHEMBL22650837 | 0.80 | CDK4 (0.41) | CDK4CCND3CDK6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |