Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650424 | 0.90 | MAP3K14 (0.39) | MAP3K14LRRK2MAP3K5EGFRCCNA2 | |
| SCHEMBL22650775 | 0.75 | CDK4 (0.44) | CCNA2CDK2 | |
| SCHEMBL22650489 | 0.73 | MAP3K14 (0.48) | MAP3K14LRRK2CCNA2CCNE1CDK2 | |
| SCHEMBL22650946 | 0.72 | CDK6 (0.44) | EGFRCCNE2CCNA2CCNE1CDK2 | |
| SCHEMBL22650856 | 0.71 | CDK6 (0.47) | CCNA2CDK2CCNA1 | |
| SCHEMBL22650859 | 0.70 | CDK4 (0.51) | CCNA2CDK2CCNA1 | |
| SCHEMBL22650734 | 0.70 | CDK6 (0.48) | CCNA2CDK2CCNA1 | |
| SCHEMBL22650549 | 0.69 | ZAP70 (0.42) | EGFRCCNA2CDK2CCNA1ACVR1 | |
| SCHEMBL22650503 | 0.68 | MAPK14 (0.46) | MAP3K14CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL22650407 | 0.68 | L3MBTL1 (0.37) | CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |