Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 16/20 | 0.42 |
| ▸ | CSF1R | P07333 | 14/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650501 | 0.89 | CDK2 (0.40) | CDK4CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL22650464 | 0.87 | CDK6 (0.44) | CDK4CDK2CCND1CDK6CSF1R | |
| SCHEMBL22650549 | 0.78 | ZAP70 (0.42) | CDK2CDK1CCNB1CCNA2CCNT1 | |
| SCHEMBL22650496 | 0.77 | EGFR (0.38) | CDK4CDK2CDK1CCNB1CCND1 | |
| SCHEMBL28686427 | 0.75 | CDK4 (0.60) | CDK4CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL29491161 | 0.74 | CDK6 (0.55) | CDK4CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL22650458 | 0.74 | CDK6 (0.55) | CDK4CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL22650949 | 0.74 | CDK6 (0.45) | CDK4CDK2CDK1CCND1CDK6 | |
| SCHEMBL22650547 | 0.72 | CDK6 (0.43) | CDK4CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL22650629 | 0.71 | CDK6 (0.41) | CDK4CDK2CCNE1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |