Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.36 |
| ▸ | CDK4 | P11802 | 5/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CCND3 | P30281 | 2/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650464 | 0.89 | CDK6 (0.44) | EGFRCDK6CDK4F10ALK | |
| SCHEMBL22650501 | 0.87 | CDK2 (0.40) | EGFRCDK4CCND1CDK1CCNA2 | |
| SCHEMBL22650549 | 0.83 | ZAP70 (0.42) | EGFRCDK1CCNA2MAP4K1CCNB1 | |
| SCHEMBL22650579 | 0.79 | CDK4 (0.48) | CDK6CDK4CCND1CDK1CCNA2 | |
| SCHEMBL22650502 | 0.77 | CDK4 (0.43) | CDK6CDK4CCND1CSF1RCDK1 | |
| SCHEMBL22650624 | 0.76 | EGFR (0.34) | EGFRCDK6CCND3 | |
| SCHEMBL22650541 | 0.76 | EGFR (0.36) | EGFRCDK4ALKCCND1MKNK1 | |
| SCHEMBL22650532 | 0.74 | EGFR (0.36) | EGFRCDK6CDK4CCND1MKNK1 | |
| SCHEMBL22650524 | 0.74 | CDK6 (0.38) | EGFRCDK6CDK4F10CCND1 | |
| SCHEMBL22650775 | 0.73 | CDK4 (0.44) | CDK6CDK4CSF1RCDK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |