Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.37 |
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | CCNK | O75909 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.36 |
| ▸ | MELK | Q14680 | 6/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650516 | 0.90 | JAK2 (0.41) | CDK4CDK6JAK2HDAC1CCND3 | |
| SCHEMBL22650518 | 0.81 | JAK2 (0.39) | CDK4CDK6JAK2HDAC1CCND3 | |
| SCHEMBL22650508 | 0.80 | JAK2 (0.38) | CDK4CDK6JAK2HDAC1CCND3 | |
| SCHEMBL22650507 | 0.76 | CDK6 (0.45) | CDK4CDK6CSF1RCCNKCCNA2 | |
| SCHEMBL22650509 | 0.73 | CDK6 (0.48) | CDK4CDK6CSF1RCCNA2CDK2 | |
| SCHEMBL22650772 | 0.70 | CDK6 (0.46) | CDK4CDK6CSF1RCCNKCCNA2 | |
| SCHEMBL22650773 | 0.70 | CDK4 (0.45) | CDK4CDK6CSF1RCCNKCCNA2 | |
| SCHEMBL22650492 | 0.69 | CDK6 (0.58) | CDK4CDK6CSF1RCCNA2CDK2 | |
| SCHEMBL22650495 | 0.65 | NOTUM (0.38) | JAK2 | |
| SCHEMBL29462387 | 0.65 | NOTUM (0.38) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |