Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650516 | 0.91 | JAK2 (0.41) | JAK2JAK3HDAC1EGFRCDK4 | |
| SCHEMBL22650508 | 0.89 | JAK2 (0.38) | JAK2JAK3HDAC1EGFRKCNH2 | |
| SCHEMBL22650517 | 0.81 | CDK4 (0.37) | JAK2HDAC1EGFRCDK4CCND3 | |
| SCHEMBL22650507 | 0.80 | CDK6 (0.45) | CDK4CCND3CDK6 | |
| SCHEMBL22650509 | 0.76 | CDK6 (0.48) | CDK4CCND3CDK6 | |
| SCHEMBL22650773 | 0.73 | CDK4 (0.45) | CDK4CCND3CDK6 | |
| SCHEMBL22650492 | 0.72 | CDK6 (0.58) | CDK4CCND3CDK6 | |
| SCHEMBL22650772 | 0.72 | CDK6 (0.46) | JAK2JAK3CDK4CCND3CDK6 | |
| SCHEMBL22650620 | 0.71 | CDK2 (0.36) | JAK2JAK3EGFRKCNH2 | |
| SCHEMBL29462408 | 0.67 | DYRK2 (0.47) | CDK4CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |