Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 9/20 | 0.36 |
| ▸ | TYK2 | P29597 | 7/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 4/20 | 0.34 |
| ▸ | CCND1 | P24385 | 4/20 | 0.34 |
| ▸ | CCND3 | P30281 | 4/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 2/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650540 | 0.93 | CCND1 (0.40) | CDK2AXLCDK4CCND1CCND3 | |
| SCHEMBL22650620 | 0.88 | CDK2 (0.36) | CDK2JAK2JAK3CDK1KCNH2 | |
| SCHEMBL22650619 | 0.81 | CDK4 (0.40) | CDK2CDK1CDK4CCND1CCND3 | |
| SCHEMBL22650630 | 0.79 | CDK9 (0.35) | CDK2JAK2JAK3CDK1KCNH2 | |
| SCHEMBL22650536 | 0.78 | JAK2 (0.34) | CDK2JAK2JAK3CDK1KCNH2 | |
| SCHEMBL22650531 | 0.75 | CDK6 (0.42) | CDK2CDK1CDK4CCND1CCND3 | |
| SCHEMBL22650578 | 0.74 | IKBKB (0.35) | CDK2JAK2JAK3CDK1KCNH2 | |
| SCHEMBL22650779 | 0.74 | CDK6 (0.42) | CDK2CDK1CDK4CCND1CCND3 | |
| SCHEMBL22650626 | 0.73 | CDK2 (0.39) | CDK2JAK2JAK3FLT3CDK1 | |
| SCHEMBL22650360 | 0.68 | SMN1; SMN2 (0.41) | CDK2CDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |