Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 10/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.40 |
| ▸ | CDK4 | P11802 | 9/20 | 0.40 |
| ▸ | CCND3 | P30281 | 9/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650535 | 0.93 | CDK2 (0.38) | CCND1CDK6CDK4CCND3CDK2 | |
| SCHEMBL22650620 | 0.87 | CDK2 (0.36) | CDK2EGFR | |
| SCHEMBL22650619 | 0.80 | CDK4 (0.40) | CCND1CDK6CDK4CCND3CDK2 | |
| SCHEMBL22650630 | 0.78 | CDK9 (0.35) | CDK2MAPK10EGFR | |
| SCHEMBL22650536 | 0.77 | JAK2 (0.34) | CDK2EGFR | |
| SCHEMBL22650782 | 0.75 | CTSC (0.40) | CCND1CDK6CDK4CCND3CDK2 | |
| SCHEMBL22650531 | 0.74 | CDK6 (0.42) | CCND1CDK6CDK4CCND3CDK2 | |
| SCHEMBL22650578 | 0.73 | IKBKB (0.35) | CDK2EGFR | |
| SCHEMBL22650626 | 0.72 | CDK2 (0.39) | CDK2MAPK10WEE1MAPK8MAPK9 | |
| SCHEMBL22650364 | 0.70 | CDK4 (0.37) | CCND1CDK6CDK4CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |