Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650778 | 0.90 | CDK4 (0.42) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650630 | 0.86 | CDK9 (0.35) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650620 | 0.86 | CDK2 (0.36) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650536 | 0.84 | JAK2 (0.34) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650578 | 0.83 | IKBKB (0.35) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650777 | 0.82 | ACVR1 (0.35) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650781 | 0.81 | IKBKB (0.39) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650537 | 0.78 | CDK2 (0.50) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650579 | 0.77 | CDK4 (0.48) | CDK2CCNA2CDK1CCNB1CCNA1 | |
| SCHEMBL22650628 | 0.76 | CDK4 (0.58) | CDK2CCNA2CDK1CCNB1CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |