SCHEMBL22650600

SCHEMBL22650600

CC(C)n1cnc2c(F)nc(-c3ccnc(Cl)n3)cc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.37
CCNA2 P20248 8/20 0.37
CDK2 P24941 8/20 0.37
CCNA1 P78396 8/20 0.37
CDK5 Q00535 8/20 0.37
CDK5R1 Q15078 8/20 0.37
DYRK1A Q13627 6/20 0.37
MAPK13 O15264 1/20 0.34
MAPK12 P53778 1/20 0.34
MAPK11 Q15759 1/20 0.34
L3MBTL1 Q9Y468 3/20 0.33
CDK1 P06493 1/20 0.33
PDE8A O60658 3/20 0.32
PDE2A O00408 1/20 0.32
PDE4D Q08499 1/20 0.32
KCNH2 Q12809 1/20 0.32
PDE10A Q9Y233 1/20 0.32
HTR3A P46098 1/20 0.31
APAF1 O14727 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29491131 1.00 MAPK14 (0.40) MAPK14SMN1; SMN2CCNA2CDK2CCNA1
SCHEMBL29491141 0.85 SMN1; SMN2 (0.37) MAPK14SMN1; SMN2CCNA2CDK2CCNA1
SCHEMBL22650407 0.83 L3MBTL1 (0.37) MAPK14SMN1; SMN2CCNA2CDK2CCNA1
SCHEMBL22650403 0.82 MAPK14 (0.35) MAPK14SMN1; SMN2CCNA2CDK2CCNA1
SCHEMBL22650364 0.79 CDK4 (0.37) MAPK14SMN1; SMN2CCNA2CDK2CCNA1
SCHEMBL22650372 0.79 SMN1; SMN2 (0.36) MAPK14SMN1; SMN2CCNA2CDK2CCNA1
SCHEMBL22650362 0.79 CDK4 (0.36) CDK2CDK1
SCHEMBL22650360 0.78 SMN1; SMN2 (0.41) SMN1; SMN2CCNA2CDK2CCNA1CDK5
SCHEMBL22650746 0.77 SMN1; SMN2 (0.45) SMN1; SMN2CCNA2CDK2CCNA1CDK5
SCHEMBL29491171 0.77 SMN1; SMN2 (0.45) SMN1; SMN2CCNA2CDK2CCNA1CDK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250281487-A1 CDK INHIBITORS GENENTECH, INC. (US) 2025-09-11 US disclosed
US-20250275972-A1 CDK INHIBITORS GENENTECH, INC. (US) 2025-09-04 US disclosed
US-20250275971-A1 CDK INHIBITORS GENENTECH, INC. (US) 2025-09-04 US disclosed
US-12285429-B2 CDK inhibitors GENENTECH, INC. (US) 2025-04-29 US disclosed
US-20250064806-A1 CDK INHIBITORS GENENTECH, INC. 2025-02-27 US disclosed
US-20240066031-A1 CDK INHIBITORS GENENTECH, INC. 2024-02-29 US disclosed
US-20240066031-A1 CDK INHIBITORS GENENTECH, INC. 2024-02-29 US disclosed
US-20240066031-A1 CDK INHIBITORS GENENTECH, INC. 2024-02-29 US disclosed
US-20240033264-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2024-02-01 US disclosed
US-20230174512-A1 CDK INHIBITORS GENENTECH, INC. 2023-06-08 US disclosed
US-20230174512-A1 CDK INHIBITORS GENENTECH, INC. 2023-06-08 US disclosed
US-20230174512-A1 CDK INHIBITORS GENENTECH, INC. 2023-06-08 US disclosed
US-20220296595-A1 CDK INHIBITORS GENENTECH, INC. 2022-09-22 US disclosed
WO-2021226140-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2021-11-11 WO disclosed
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250281487-A1 CDK INHIBITORS CDK6, CDK9, CDKL1 MAPK14 238/4885SMN1; SMN2 2041/4885CCNA2 41/4885
US-20240033264-A1 CDK INHIBITORS CDK9, CDKL1, CDK3 MAPK14 196/4885SMN1; SMN2 2631/4885CCNA2 41/4885
US-20240066031-A1 CDK INHIBITORS CDK9, CDKL1, CDK3 MAPK14 196/4885SMN1; SMN2 2631/4885CCNA2 41/4885
US-20250064806-A1 CDK INHIBITORS CDK9, CDK6, CDK3 MAPK14 190/4885SMN1; SMN2 2777/4885CCNA2 39/4885
US-12285429-B2 CDK inhibitors CDK9, CDK3, CDKL1 MAPK14 200/4885SMN1; SMN2 2470/4885CCNA2 39/4885
US-20250275972-A1 CDK INHIBITORS CDK9, CDK6, CDK3 MAPK14 190/4885SMN1; SMN2 2777/4885CCNA2 39/4885
US-20220296595-A1 CDK INHIBITORS CDKL1, CDK9, CDK6 MAPK14 170/4885SMN1; SMN2 2350/4885CCNA2 41/4885
US-20230174512-A1 CDK INHIBITORS CDK9, CDKL1, CDK3 MAPK14 196/4885SMN1; SMN2 2631/4885CCNA2 41/4885
US-20250275971-A1 CDK INHIBITORS CDK6, CDK9, CDKL1 MAPK14 238/4885SMN1; SMN2 2041/4885CCNA2 41/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.