Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK1 | Q8N5S9 | 3/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADH5 | P11766 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650436 | 0.80 | RPS6KA5 (0.34) | RPS6KA5SCN5AMAPTPOLBCASP6 | |
| SCHEMBL22650356 | 0.77 | SCN5A (0.39) | RPS6KA5SCN5A | |
| SCHEMBL22650740 | 0.77 | RPS6KA5 (0.32) | CAMKK2RPS6KA5 | |
| SCHEMBL22650437 | 0.72 | SCN5A (0.42) | RPS6KA5SCN5AMAPTPOLBCASP6 | |
| SCHEMBL22650698 | 0.72 | MAPK14 (0.35) | MAPK1CDK2PIK3CA | |
| SCHEMBL31334301 | 0.71 | KMT2A (0.38) | KMT2AMAPTCCNA2CDK2CDK6 | |
| SCHEMBL19966454 | 0.70 | KMT2A (0.40) | KMT2ACCNA2CDK2PIK3CACDK6 | |
| SCHEMBL28987249 | 0.70 | KMT2A (0.40) | KMT2ACDK2PIK3CACDK6 | |
| SCHEMBL30278677 | 0.70 | KMT2A (0.40) | KMT2ACDK2PIK3CACDK6 | |
| SCHEMBL15252527 | 0.69 | CDK9 (0.51) | MAPTCDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |