SCHEMBL22650437

SCHEMBL22650437

Fc1cnc(Cl)nc1-c1ccn2nccc2c1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 1/20 0.42
RPS6KA5 O75582 2/20 0.38
PIK3CD O00329 2/20 0.37
MAPT P10636 1/20 0.35
RPS6KA4 O75676 1/20 0.32
POLB P06746 1/20 0.32
CASP6 P55212 1/20 0.32
DYRK1A Q13627 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MET P08581 2/20 0.31
BTK Q06187 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650436 0.76 RPS6KA5 (0.34) SCN5ARPS6KA5MAPTPOLBCASP6
SCHEMBL22650356 0.74 SCN5A (0.39) SCN5ARPS6KA5SMN1; SMN2
SCHEMBL22650740 0.74 RPS6KA5 (0.32) RPS6KA5SMN1; SMN2
SCHEMBL15229110 0.73 ADORA2B (0.44) MAPTDYRK1A
SCHEMBL15577176 0.72 BTK (0.46) MAPTBTK
SCHEMBL22650908 0.72 CAMKK1 (0.38) SCN5ARPS6KA5MAPTPOLBCASP6
SCHEMBL15639555 0.71 KMO (0.41) SCN5APOLB
SCHEMBL3758203 0.71 KDM4E (0.52) RPS6KA5MAPTSMN1; SMN2
SCHEMBL19078912 0.71 MAPT (0.42) MAPTSMN1; SMN2BTK
SCHEMBL31334102 0.71 MAPT (0.42) MAPTSMN1; SMN2BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120040446-A CDK inhibitors 基因泰克公司 2025-05-27 CN disclosed
US-20220296595-A1 CDK INHIBITORS GENENTECH, INC. 2022-09-22 US disclosed
EP-3966213-A1 CDK INHIBITORS Qilu Regor Therapeutics Inc. (CN) 2022-03-16 EP disclosed
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220296595-A1 CDK INHIBITORS CDKL1, CDK9, CDK6 SCN5A 3231/4885RPS6KA5 342/4885PIK3CD 395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.