Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.42 |
| ▸ | NEK3 | P51956 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650923 | 0.89 | MAPK8 (0.54) | CDK2KCNH2CDK4CDK1CCNB1 | |
| SCHEMBL22650920 | 0.88 | CDK2 (0.54) | CDK2KCNH2CDK4CDK1CCNB1 | |
| SCHEMBL22650921 | 0.85 | MTOR (0.49) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL22650800 | 0.85 | IKBKB (0.46) | CDK2KCNH2CDK4CDK1CCNB1 | |
| SCHEMBL22650851 | 0.84 | IKBKB (0.56) | CDK2CDK1SYKMYLK4STK17A | |
| SCHEMBL22650796 | 0.84 | CDK2 (0.44) | CDK2KCNH2CDK4CDK1CCNB1 | |
| SCHEMBL22650849 | 0.83 | CDK1 (0.47) | CDK2CDK1JAK3MYLK4STK17A | |
| SCHEMBL22650853 | 0.83 | CDK1 (0.52) | CDK2CDK1SYKMYLK4STK17A | |
| SCHEMBL22650927 | 0.82 | CDK2 (0.52) | CDK2KCNH2CDK4CDK1CCNB1 | |
| SCHEMBL22650918 | 0.82 | DKK1 (0.57) | CDK2CDK1CCNB1JAK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |