Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 11/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CCNH | P51946 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650923 | 0.85 | MAPK8 (0.54) | GSK3BIKBKBMAPK8MAPK10CDK2 | |
| SCHEMBL22650852 | 0.84 | CDK2 (0.59) | IKBKBCDK2CCNT1CDK1CCNB1 | |
| SCHEMBL22650920 | 0.83 | CDK2 (0.54) | MAPK8MAPK10CDK2CDK1CCNB1 | |
| SCHEMBL22650919 | 0.82 | CDK2 (0.54) | GSK3BMAPK8MAPK10CDK2CDK1 | |
| SCHEMBL22650921 | 0.80 | MTOR (0.49) | IKBKBCDK2SMG1CDK1CCNB1 | |
| SCHEMBL22650595 | 0.79 | PRKCA (0.40) | GSK3BCDK2CCNT1CDK1CCNB1 | |
| SCHEMBL22650796 | 0.78 | CDK2 (0.44) | IKBKBCDK2SMG1CDK1CCNB1 | |
| SCHEMBL22650422 | 0.78 | CDK1 (0.41) | CDK2CCNT1CDK1CCNB1CDK9 | |
| SCHEMBL22650849 | 0.78 | CDK1 (0.47) | IKBKBCDK2SMG1CDK1MTOR | |
| SCHEMBL22650482 | 0.77 | CDK1 (0.59) | GSK3BCDK2CCNT1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |