Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.36 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 5/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.33 |
| ▸ | CD69 | Q07108 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650524 | 0.88 | CDK6 (0.38) | F10CDK6CCND3MAP4K1CDK4 | |
| SCHEMBL22650598 | 0.84 | EGFR (0.37) | CCND3CDK4CCNA2CCND1EGFR | |
| SCHEMBL22650428 | 0.83 | CDK4 (0.35) | CDK6CCND3CDK4CDK1CCNA2 | |
| SCHEMBL22650763 | 0.81 | CDK4 (0.47) | CDK6CCND3CDK4CDK1CCNA2 | |
| SCHEMBL22650937 | 0.80 | CDK4 (0.40) | CDK6CCND3MAP4K1CDK4CDK1 | |
| SCHEMBL22650432 | 0.78 | CDK6 (0.35) | CDK6CCND3CDK4CDK1CCNA2 | |
| SCHEMBL22650526 | 0.76 | MAP4K1 (0.44) | CDK6MAP4K1CDK4CDK1CCNA2 | |
| SCHEMBL29491175 | 0.75 | CDK4 (0.49) | CDK6CCND3MAP4K1CDK4CDK1 | |
| SCHEMBL22650568 | 0.75 | CDK4 (0.49) | CDK6CCND3MAP4K1CDK4CDK1 | |
| SCHEMBL22650922 | 0.75 | F10 (0.38) | F10EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |