Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | CDK4 | P11802 | 15/20 | 0.43 |
| ▸ | CDK2 | P24941 | 13/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 13/20 | 0.43 |
| ▸ | CDK1 | P06493 | 6/20 | 0.41 |
| ▸ | CDK7 | P50613 | 5/20 | 0.41 |
| ▸ | CDK9 | P50750 | 5/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650774 | 0.90 | CDK4 (0.51) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL29491157 | 0.86 | MAPT (0.45) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22650775 | 0.78 | CDK4 (0.44) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22650856 | 0.71 | CDK6 (0.47) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22650860 | 0.70 | CDK6 (0.44) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22650429 | 0.69 | CCND1 (0.40) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22650859 | 0.69 | CDK4 (0.51) | JAK2JAK3CDK4CDK2CDK6 | |
| SCHEMBL22650734 | 0.69 | CDK6 (0.48) | JAK2CDK4CDK2CDK6CDK1 | |
| SCHEMBL22650857 | 0.68 | CDK6 (0.45) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22650407 | 0.65 | L3MBTL1 (0.37) | CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |