Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 9/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17942340 | 0.81 | ALDH1A1 (0.44) | ARANO1JAK2JAK1TYK2 | |
| SCHEMBL28663446 | 0.81 | KDM4E (0.55) | ARANO1SMARCA2SMARCA4SORT1 | |
| SCHEMBL22670384 | 0.80 | AR (0.48) | ARANO1 | |
| SCHEMBL23405316 | 0.79 | ANO1 (0.47) | ANO1JAK2TYK2SMARCA2SMARCA4 | |
| SCHEMBL15880501 | 0.78 | PRKCI (0.62) | ARJAK2JAK1TYK2PRKCI | |
| SCHEMBL28292635 | 0.78 | SCN10A (0.44) | ARANO1SMARCA2SMARCA4SORT1 | |
| SCHEMBL30885027 | 0.78 | UHRF1 (0.43) | KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2643034 | 0.78 | UHRF1 (0.43) | KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL28294352 | 0.77 | RAF1 (0.43) | ARANO1TYK2SMARCA2SMARCA4 | |
| SCHEMBL15880685 | 0.75 | SMARCA2 (0.65) | SMARCA2SMARCA4SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983386-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | Metabomed Ltd (IL) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020230136-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD (IL) | 2020-11-19 | — | — | WO | disclosed |