Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883725 | 0.83 | PIK3C3 (0.41) | RAF1ALDH1A1KDM4EPIK3C3TYK2 | |
| SCHEMBL17942340 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMARCA2SMARCA4ANO1 | |
| SCHEMBL28663446 | 0.81 | KDM4E (0.55) | ALDH1A1KDM4ESMARCA2SMARCA4ANO1 | |
| SCHEMBL2437319 | 0.79 | ALDH1A1 (0.41) | RAF1ALDH1A1KDM4EPIK3C3ANO1 | |
| SCHEMBL2437324 | 0.79 | ALDH1A1 (0.38) | RAF1ALDH1A1KDM4EPIK3C3TYK2 | |
| SCHEMBL23405316 | 0.79 | ANO1 (0.47) | RAF1SMARCA2SMARCA4ANO1SORT1 | |
| SCHEMBL28292635 | 0.78 | SCN10A (0.44) | RAF1ALDH1A1KDM4ESMARCA2SMARCA4 | |
| SCHEMBL4947098 | 0.78 | ALDH1A1 (0.44) | RAF1ALDH1A1KDM4EPIK3C3MAPT | |
| SCHEMBL22658181 | 0.77 | AR (0.45) | ALDH1A1KDM4ESMARCA2SMARCA4ANO1 | |
| SCHEMBL5700562 | 0.76 | ALDH1A1 (0.43) | RAF1ALDH1A1KDM4EPIK3C3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |