Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM5A | P29375 | 2/20 | 0.55 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.55 |
| ▸ | TET3 | O43151 | 1/20 | 0.55 |
| ▸ | KDM4A | O75164 | 1/20 | 0.55 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KDM5C | P41229 | 1/20 | 0.55 |
| ▸ | ASPH | Q12797 | 1/20 | 0.55 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.55 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.55 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.55 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.55 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.55 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.55 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.55 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17942340 | 0.85 | ALDH1A1 (0.44) | KDM4EALDH1A1KDM5AKDM3AKDM6B | |
| SCHEMBL5906610 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1KDM5AKDM3AKDM6B | |
| SCHEMBL28292635 | 0.85 | SCN10A (0.44) | KDM4EALDH1A1KDM5AKDM3AKDM6B | |
| SCHEMBL23405316 | 0.82 | ANO1 (0.47) | SORT1NPC1RAB9ASMARCA2SMARCA4 | |
| SCHEMBL28294352 | 0.81 | RAF1 (0.43) | KDM4EALDH1A1MAPTSORT1L3MBTL1 | |
| SCHEMBL22658181 | 0.81 | AR (0.45) | KDM4EALDH1A1SORT1NPC1RAB9A | |
| SCHEMBL23488122 | 0.81 | KCNK3 (0.66) | KDM4EALDH1A1KDM5AKDM3AKDM6B | |
| SCHEMBL1251612 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1KDM5AKDM3AKDM6B | |
| SCHEMBL25301796 | 0.80 | SMARCA2 (0.69) | KDM4EALDH1A1KDM5AKDM3AKDM6B | |
| SCHEMBL31140004 | 0.80 | SMARCA2 (0.69) | KDM4EALDH1A1KDM5AKDM3AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114213415-A | Macrocyclic pyrimidine derivatives | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-106164075-B | Macrocyclic pyrimidine derivatives | 詹森药业有限公司 | 2021-11-26 | — | — | CN | disclosed |