Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22670292 | 0.85 | RXFP1 (0.52) | TP53SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL29467538 | 0.81 | RAB9A (0.55) | TP53SMN1; SMN2MAPTRAB9AHTT | |
| SCHEMBL25007307 | 0.80 | PTPN5 (0.48) | — | |
| SCHEMBL30222787 | 0.80 | PTPN5 (0.48) | — | |
| SCHEMBL22670274 | 0.78 | TSHR (0.46) | TP53SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL29433296 | 0.78 | TSHR (0.46) | TP53SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL25006865 | 0.78 | RIPK1 (0.41) | MAPTMEN1KMT2ARAB9AHTT | |
| SCHEMBL30222838 | 0.78 | RIPK1 (0.41) | MAPTMEN1KMT2ARAB9AHTT | |
| SCHEMBL17925886 | 0.75 | MEN1 (0.57) | TP53SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2096025 | 0.75 | MAPT (0.75) | TP53SMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983386-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | Metabomed Ltd (IL) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020230136-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD (IL) | 2020-11-19 | — | — | WO | disclosed |