Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24128943 | 0.89 | TAAR1 (0.53) | TAAR1MAPK1SLC6A4MAPTCYP1A2 | |
| SCHEMBL5331937 | 0.79 | ADORA1 (0.47) | MAPK1HSP90AB1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL25412219 | 0.74 | ALDH1A1 (0.44) | TAAR1SLC6A4CYP3A4ALDH1A1SLC6A2 | |
| SCHEMBL109195 | 0.73 | TAAR1 (0.64) | TAAR1SLC6A4MAPTCYP1A2CYP3A4 | |
| SCHEMBL108109 | 0.71 | TAAR1 (0.62) | TAAR1SLC6A4MAPTCYP1A2CYP3A4 | |
| SCHEMBL19341768 | 0.71 | GFER (0.47) | ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL18197881 | 0.69 | MET (0.55) | MAPK1SLC6A4MAPTCYP1A2CYP3A4 | |
| SCHEMBL108087 | 0.69 | TAAR1 (0.77) | TAAR1SLC6A4MAPTCYP1A2CYP3A4 | |
| SCHEMBL19328356 | 0.69 | CNR2 (0.47) | TAAR1ALDH1A1KMT2A | |
| SCHEMBL25414316 | 0.68 | ALDH1A1 (0.46) | MAPK1HSP90AB1HSD17B10ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963329-B1 | INHIBITORS OF C-MET AND USES THEREOF | VERTEX PHARMA (US) | 2013-01-23 | — | — | EP | disclosed |
| EP-1963329-B1 | INHIBITORS OF C-MET AND USES THEREOF | VERTEX PHARMA (US) | 2013-01-23 | — | — | EP | disclosed |
| US-7998987-B2 | Inhibitors of c-Met and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998987-B2 | Inhibitors of c-Met and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100190774-A1 | INHIBITORS OF C-MET AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-07-29 | — | — | US | disclosed |
| US-20100190774-A1 | INHIBITORS OF C-MET AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-07-29 | — | — | US | disclosed |
| US-7728017-B2 | Inhibitors of c-Met and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728017-B2 | Inhibitors of c-Met and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070191369-A1 | Inhibitors of c-Met and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191369-A1 | Inhibitors of c-Met and uses thereof | MET, HGF, ABL1 | TAAR1 3283/4885LTB4R 3403/4885MAPK1 945/4885 |
| US-20100190774-A1 | INHIBITORS OF C-MET AND USES THEREOF | MET, HGF, ABL1 | TAAR1 3283/4885LTB4R 3403/4885MAPK1 945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.