Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26639786 | 0.88 | KDM1A (0.39) | KDM1AMAOAMAOBCYP2C19ADRB2 | |
| SCHEMBL297140 | 0.87 | KDM1A (0.50) | KDM1AMAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL12266677 | 0.79 | KDM4E (0.41) | KDM1AMAOAMAOBKDM4ETRPV4 | |
| SCHEMBL30471873 | 0.79 | KDM1A (0.47) | KDM1AMAOAMAOBCYP3A4KDM4E | |
| SCHEMBL23545596 | 0.79 | KDM1A (0.47) | KDM1AMAOAMAOBCYP3A4KDM4E | |
| SCHEMBL27975333 | 0.78 | TRPV4 (0.35) | KDM1AMAOAMAOBKCNQ3KCNQ2 | |
| SCHEMBL14552496 | 0.78 | ESR1 (0.41) | KDM1AMAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL1743280 | 0.78 | TKT (0.39) | KDM1AMAOAMAOBTRPV4 | |
| SCHEMBL8927734 | 0.78 | TRPV4 (0.35) | KDM1AMAOAMAOBTRPV4 | |
| SCHEMBL8190374 | 0.78 | LOXL2 (0.42) | KDM1AMAOAMAOBADRB2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738961-A1 | HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF | Medshine Discovery Inc. (CN) | 2020-11-18 | — | — | EP | disclosed |