Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 3/20 | 0.34 |
| ▸ | TKT | P29401 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | MLYCD | O95822 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9694886 | 0.84 | CCR9 (0.37) | — | |
| SCHEMBL934644 | 0.84 | TRPV4 (0.52) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL12266677 | 0.82 | KDM4E (0.41) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL8190374 | 0.81 | LOXL2 (0.42) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL27975333 | 0.81 | TRPV4 (0.35) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL1743280 | 0.81 | TKT (0.39) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL14552496 | 0.81 | ESR1 (0.41) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL24973976 | 0.78 | ALDH1A1 (0.37) | TRPV4DAOPPARDMLYCD | |
| SCHEMBL1958711 | 0.78 | DAO (0.40) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL22663449 | 0.78 | KDM1A (0.40) | TRPV4KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240190865-A1 | T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-06-13 | — | — | US | disclosed |
| WO-2024081653-A2 | METHODS OF LOWERING MIRO2 TO TREAT NEURODEGENERATIVE DISEASES | ACUREX BIOSCIENCES CORPORATION (US) | 2024-04-18 | — | — | WO | disclosed |
| EP-4301759-A2 | T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF | The Board of Trustees of the Leland Stanford Junior University (US) | 2024-01-10 | — | — | EP | disclosed |
| CN-116917289-A | T-type calcium channel antagonists and uses thereof | 小利兰·斯坦福大学董事会 | 2023-10-20 | — | — | CN | disclosed |
| WO-2022216386-A9 | T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2022-12-01 | — | — | WO | disclosed |
| WO-2022216386-A2 | T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2022-10-13 | — | — | WO | disclosed |
| EP-2338882-B1 | 2-((6-(Haloalkyl substituted))pyridin-3-yl)-tetrahydro-1H-1(lamba)4-thien-1-ylidenecyanamide derivatives and related compounds as pesticides and insecticides | DOW AGROSCIENCES LLC (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9125412-B2 | Stable insecticide compositions and methods for producing same | DOW AGROSCIENCES LLC (US) | 2015-09-08 | — | — | US | disclosed |
| US-9125412-B2 | Stable insecticide compositions and methods for producing same | DOW AGROSCIENCES LLC (US) | 2015-09-08 | — | — | US | disclosed |
| US-9012654-B2 | Insecticidal N-substituted (6-haloalkylpyridin-3-yl)-alkyl sulfoximines | DOW AGROSCIENCES LLC (US) | 2015-04-21 | — | — | US | disclosed |
| US-7687634-B2 | Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines | DOW AGROSCIENCES LLC (US) | 2010-03-30 | — | — | US | disclosed |
| WO-2009014891-A2 | INCREASING PLANT VIGOR | DOW AGROSCIENCES LLC (US) | 2009-01-29 | — | — | WO | disclosed |
| US-20090023782-A1 | INCREASING PLANT VIGOR | DOW AGROSCIENCES LLC (IN) | 2009-01-22 | — | — | US | disclosed |
| US-20090023782-A1 | INCREASING PLANT VIGOR | DOW AGROSCIENCES LLC (IN) | 2009-01-22 | — | — | US | disclosed |
| US-20080280915-A1 | Insecticidal n-substituted (heteroaryl)alkyl sulfilimines | CORTEVA AGRISCIENCE LLC | 2008-11-13 | — | — | US | disclosed |
| US-20080280915-A1 | Insecticidal n-substituted (heteroaryl)alkyl sulfilimines | CORTEVA AGRISCIENCE LLC | 2008-11-13 | — | — | US | disclosed |
| WO-2008030266-A2 | INSECTICIDAL N-SUBSTITUTED (HETEROARYL)ALKYL SULFILMINES | DOW AGROSCIENCES LLC (US) | 2008-03-13 | — | — | WO | disclosed |
| US-20070203191-A1 | Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines | CORTEVA AGRISCIENCE LLC | 2007-08-30 | — | — | US | disclosed |
| US-20070203191-A1 | Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines | CORTEVA AGRISCIENCE LLC | 2007-08-30 | — | — | US | disclosed |
| WO-2007095229-A2 | INSECTICIDAL N-SUBSTITUTED (6-HALOALKYLPYRIDIN-3-YL)ALKYL SULFOXIMINES | DOW AGROSCIENCES LLC (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240190865-A1 | T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF | CACNA1G, CACNA1H, CACNB2 | TRPV4 59/4885DAO 519/4885TKT 4471/4885 |
| US-20080280915-A1 | Insecticidal n-substituted (heteroaryl)alkyl sulfilimines | AANAT, GNMT, STS | TRPV4 4208/4885DAO 663/4885TKT 4292/4885 |
| US-20090023782-A1 | INCREASING PLANT VIGOR | HDLBP, VPS4B, VPS28 | TRPV4 3503/4885DAO 1987/4885TKT 1844/4885 |
| US-20070203191-A1 | Insecticidal N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines | NPEPPS, PRDX6, HDHD5 | TRPV4 1575/4885DAO 124/4885TKT 3272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.